Home GlycoBase
The National Institute for Bioprocessing Research and Training (NIBRT)
Dublin-Oxford Glycobiology Laboratory (NIBRT/UCD)
PI: Prof. Pauline Rudd
Please note that from January 1st 2009 all non-academic users of GlycoBase will be required to accept terms and coniditions of use and to register with NIBRT. For more information please contact NIBRT.
The EUROCarbDB beta Database will be jointly hosted at NIBRT for user testing and validation
GlycoBase: A novel database containing published details on 2-aminobenzamide (2AB) labelled released glycans. Each glycan entry is comprehenisvely annotated with a glucose unit (GU) value, monosaccharide composition, exoglycosidase digestion pathways, MS and MS/MS evidence together with each PubMed reference. Where glycans have been reported more than once, an average GU value is presented along with the standard deviation.
We intend to update the number of structures on a regular basis reflecting group publications including O-linked structures. The database is part of the EUROCarbDB project (www.eurocarbdb.org) to provide a comprehensive resource of glycan data for the communtiy.
We would like to expand the number of glycans identified with different labels and HPLC techniques, therefore, any groups interested in distributing data via GlycoBase and EUROCarbDB are invited to contact Matthew Campbell (matthew.campbell [@] nibrt.ie). A majority of the glycans were characterised at the Oxford Glycobiology Institute.
AutoGU: This program allows the matching of GU data from HPLC profiles with GlycoBase to produce a list of possible glycan structures. Where exoglycosidase digestion profiles are also available this program can be used to narrow down the number of possible structures by taking into account the digestion footprint of each possible glycan. Final assignments of the complete glycan pool are produced when the total glycan profile results all match with the digestion profiles.
AutoGu is a database matching software which assigns structures based on GU values and subsequent shifts due to exoglycosidase digestions.
GlycoBase Selection Options
The following options are designed to narrow the number of glycans presented. To see all glycan structures click here GlycoBase and associated tools are free for academic use. Industry should acquire a technology transfer agreement before commerical use!